genosmart DX Lung Cancer ^PlasmaDNA-1

Circulating tumor DNA testing to monitor lung cancer status

Useful for

The genosmartDX Lung Cancer PlasmaDNA-focus is a targeted resequencing assay for the analysis of hotspots in 11 genes with known relevance to lung cancer therapies. The assay is circulating tumour DNA based and identifies variations from the plasma. ONE of the following 29 targets of the 11 lung cancer related genes are monitored: ALK I1171, ALK G1202, ALK G1269, BRAF V600E, EGFR G719, EGFR K745-N756, EGFR T790M, EGFR L858, EGFR L861, HER2 G309, HER2 S310, HER2 L755-D769, HRAS G12, HRAS G13, HRAS Q61, KRAS G12, KRAS G13, KRAS Q61, MET D1010, NRAS Q61, PIK3CA E542, PIK3CA E545, PIK3CA H1047, ROS1 G2032, ROS1 L2155, TP53 5.-8. exon

Speciment type requirements

2x ~10 ml of blood in PAX or Streck tubes

Required information

Known variants in the tumour/previous plasma sample

Clinical interpretation

Targeted cancer therapies are defined as antibody or small molecule drugs that block the growth and spread of cancer by interfering with specific cell molecules involved in tumour growth and progression. Multiple targeted therapies have been approved for treatment of specific cancers. Molecular genetic profiling is often needed to identify targets amenable to targeted therapies and to minimize treatment costs and therapy-associated risks.

Cautions

This test cannot differentiate between somatic and germline alterations. Additional testing may be necessary to clarify the significance of results if there is a potential hereditary risk. DNA variants of uncertain significance may be identified. A negative (wild-type) result does not rule out the presence of a mutation that may be present but below the limits of detection of this assay. Rare polymorphisms may be present that could lead to false-negative or false-positive results. Test results should be interpreted in the context of clinical findings, tumour sampling, and other laboratory data. If results obtained do not match other clinical or laboratory findings, please contact the laboratory for updated interpretation. Misinterpretation of results may occur if the information provided is inaccurate or incomplete.